1 3/4" Headers Verses 1 7/8" on a Healthy 408....Is There a Big Difference??

I absolutely wouldn't spend the time and money to upgrade them. Even if you gained 10 HP and I really doubt that. You'll end up losing TQ in the RPM range.

FYI: I have 1-7/8" headers on a very well built 499 RB and that's all the header that engine needs.

Tom

I just posted my personal results and the gains I saw on a small block stroker. Have to disagree with you, his car will love the 1 7/8 header a lot more than 10 horsepower. I saw nearly 40 horse gain with doing nothing but switching headers.
I documented it well on here with timeslips.
Those street TTI headers are a limiting factor above 550 horsepower, no doubt about it.