hughes or comp camshaft

Neither.
You need more cam for the 4'' arm, more stroke eats up duration and will lower the advertised power range of the cams ur looking at, the motor will run out of steam way before you think.
I look for around 248-254*@ .050 with a mild 408/4'' arm sb
run this one for the hughes

http://www.hughesengines.com/Index/...&level2=RmxhdCBUYXBwZXQsIFNvbGlk&partid=21801

or this one from comp

http://www.compcams.com/Company/CC/cam-specs/Details.aspx?csid=671&sb=2

yes, the rockers will survive.

The hyd flat tappet 292H cam from Comp is also a nice one. Mine is 10-1 CR, eddy heads, single plane manifold and makes 500HP at 6000. Nice idle too. Cam starts waking up at about 2500.