3/8 fuel line routing?

Has anyone have the best route to run new 3/8 fuel line on my duster. Was gona run along factory lines but that's a lot of bending and that's a bit ch to run around frame by the wheel wells on rear.or can I get away with running straight down the inside rear frame rail. But then I would be 2" away from muffler ? Is that way to close? Any opinions. ? #-on