Cooling Difference in Aluminum heads?

base timing 10*, idle timing 22*. Engine starts at 10 and computer adds 12* for 22* after start, dizzy is locked out.
This is all chinese to me.
The base timing is the same as initial timing, and it better be the same as idle-timing.
But if you have a computer controlling the timing, well then I don't like your numbers, and you failed to mention the" all-in" power-timing and when it occurs and what you are doing for VA.
The all-in power-timing needs to be in the 32/34 degree range., and
It needs to be all-in by 3400 to as early as 3000,and
a streeter IMO, HAS to have a working and well tuned VA.

I don't know where you got the idea that a 2.66 low 5-speed is a close ratio tranny, cuz it's not,(unless it was compared to another wider ratio tranny in the same manufacturers line-up), but none-the less; a 5-speed with a 2.66 low and 3.23s and a .68OD is also messed up.
My combo didn't come alive until I hit nearly 11/1 starter gear. For you, that would be 11/2.66=4.10s and the hiway gear would be 4.10 x .68=2.79s, just about perfect. For optimum forward motion with a 222 cam,your shift rpm will be about 5800rpm, perhaps a little less.
If you are running something like these ratios; 2.66-1.91-1.39-1.00-.68od, then the splits are about 71/72%. Theses work great with that 222* cam, dropping the Rs to about 4200 on the shift, just a little above the torque peak.
Of course the 3.23s will work, if a bit lazy outta the gate. And cruising 65=1800 ain't bad, and again the 222 cam will pull a hiway gear down to about 1500, so if hiway cruising is your thing, then the 3.23s gotta stay.
But, for optimum fuel-mileage, the cruise timing at 1800 will need to get up around 45 to 50 degrees perhaps even more.Then you can lean the heck out of the low-speed circuit and target fuel mileage in the mid 20s,mpg.

To recap
Idle timing about 14(with a stick),
power-timing of 32/34*(aluminum heads).
All-in by 3400 to 3000
VA of 22*, in ASAP
Minimum gear for performance, of 3.73 , 3.91s preferred
With the 3.91s, and all in no sooner than 3400,you will probably find that it will run fine full load-WOTon 87E10(mine always has). In all cases, it will be happy with 87 on the hiway.
Now, I'll tell you a secret;
The 3.91s will get you shift rpm at 45mph with 27" tires.Whereas with 3.23s,this will not occur until 54 mph,9 mph later. That means you just put down all your horsepower 9 mph sooner, and so the average power put down during the timespan it took, will have been much closer to the peak horsepower that the engine is capable of producing. In other words this is the quick way.
And now you are set up to pull second gear, which will hit 60 at 5600, just after peak power,perfect. Whereas with the 3.23s you will hit 60 at 4600, barely past peak torque, and fully 800rpm too soon.
If these things matter to you.