Activating MDS

I dont think that's possible with the carb set up. I have that engine in my durango. My understanding of how it works is that it basically shuts not only spark off to the cylinders but turns the fuel injectors off. If you try to do it with a carb conversion on it, the closed cylinder intake port is still gonna get filled with fuel, thus flooding that cylinder when it does open back up, plus the carb cant automatically adjust to run leaner, thus flooding the other 4 cylinders. Plus the whole set up relies on electronically controlled lifter and an electric throttle position sensor/control. you have none of that with the carb set up. there's also a special sensor per cylinder that takes into account the oil pressure per cylinder. Only way to make it work is with fuel injection.
How are the cylinders going to get filled if the valves are closed? It's a carb, so the cylinders that are operating will draw the fuel. Raw fuel is not dropped with a carb, air pulled in by the pistons pull the fuel into the cylinders. What I don't know is that it's jetted for a 5.7L, if it's operating as a 3.35L, will it be pig rich??? Why can't I have a TPS on a carb? I do have the harness that has the sensors and solenoids... The factory system is mostly seamless and operates at slower speeds, as well as cruising, I'm interested in cruising speeds.

What happens if the solenoids are turned on and off, without any sensors? I bet it drops the 4 cylinders... Now, like you said, timing of the sequence might be critical to not back fire or pop, maybe it waits till after each exhaust stroke, then closes everything...

I'm a ways off from starting it up, but that might be a good experiment even at idle.. Wideband sensors, and power the solenoids on off....