Yes, it will out cool a 3 or 4 core radiator.
That said, if you don't want to drill extra holes in your core support and trim some of the brackets on the radiator, look for a different brand.
They cool like jack the bear, but they are not a drop in fit. Other than that, they work.
As I've posted before, I'd look into the Cold Case radiator very close before I bought anything else. They are a sponsor here. And they say theirs is a drop in fit.
A for sure, use a big 2 core radiator. More cores is NOT better.