Engine pre run oil pump

What I know is that nearly every engine I have ever owned eventually develops bottom end noise for a second or two at startup. My 2014 F150 with 80,000 miles and synthetic oil has it now after religiously warming up before driving and oil changes at 5000 miles whether it needs it or not. I drive 100 miles round trip to work and back. Sure engine oils and fuels have anti wear agents in them but when the rods and mains aren't in a fluid floating state, scuffing can occur... that is what I want to avoid. I would think that in a higher compression motor the scuffing effect may be even worse.