Pure stock drag racing

Ya I'm still here. But only by the grace of god. But I still can not figure out how a New School tuner can tune a car with only one O2 sensor. I know it's in the software but unless everone (intake manifolds, headers, fuel injector resistance & flow and each cylinder psi ect.) got it right and 100% how do you do it? ps even the factory uses 2 and race cars use 8.
Even engines tuned with a computer have spark plugs. Read the plugs.