Try it and see, read plugs and go easy with the tune so sneak up on it. There's more to detonation than just octane, same guy said he'd managed 21-1 compression on pump fuel BUT this guy was in his own league.
I've definitely got a new learning curve to figure out now, since this will be my 1st tunnel ram deal ported with 2- 850s, if this was a street car I'd go all in on tuning it for pump gas and surely the plugs will tell the tale.