Is it possible for 318 to run with dist. 180 deg. off ???

6 is 180° off. Many guys get mixed up when installing a cam and timing set. THe cam gear mark and the crank gear mark should both be at 12:00 position for #1 to be at TDC. If you line the marks up together, #6 will be up. (timing marks at 6 and 12) One thing nice about Mopar distributors, the drive tang goes in at tdc or 180 off. If you mess up, pull the distributor, twist the rotor a half turn and set it back in the hole. Back to TDC.

180* out and it's firing cyls in overlap, results in big. KABOOM .