Sounds like the exact same thing I went through with my Ford E150 5.4 Triton, missfire codes.
Replaced all spark plugs and all coil packs, the Good Denzo coils through Rock Auto with Motocraft Plugs for the Ford.
Running like a million bucks now. 2 day job all crammed up underneath the firewall on those vans. Took my time and got it right.
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In a pinch I was out on the road with a long ways to go yet > cross country, with the missfiring going on.
Had a new can of WD-40 with me, sprayed down the coil packs and the coil down necks into the heads and the electrical connectors on the coils. This helped the coils to stop shorting out to the ground of the head, insulating them with the penetrating oil.
It was back to full power after that. The thing is the coil packs short out to the cylinder heads (block) after they get too much time on them or are exposed to moisture, then they will short. (think those insulating boots dry out and go bad too, all part of the problem)
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