Would this set up be desireable in my 66 Cuda?

RobbAdams said

The fellow says it has a bigger cam than stock, but cannot recall the specs. and has standard compression pistons.

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The thing is that if it's standard compression 318 pistions and you put 340 heads on the motor, this will drop the compression ratio drastically. So it's not just about the pistons, it also has to do with the possible non 318 heads that might be on the motor. This is just assuming that when you originally talked about the motor being a '318 / 340' - the motor is a 318 with 340 heads.