I really can't offer an opinion, never played with any system though I have a few customers who do (in conjunction with intercoolers too)
The Reliant always ran 110 octane race fuel so using meth as an octane booster wan't really needed and the small amount of fuel used at the track wasn't a hardship.
Air to air intercooler was the weapon of choice following the "Keep It Simple Stupid" school of thought. The next drivetrain with have air to ice water in a bid to maximize HP.