Opinion: Small motors more or less consistent than big motors?

I think in terms of repeatable, you have to remove any other variable than the engine to even consider this. It's all hypothetical, but if you do that, I think the more scienced out engine will be more repeatable. Note I did not say "most hp". I said most scienced out. Because the more "figured out" an engine package is, the less the affects of climate will affect it. If I was building a bracket car, I'd want a pump gas reliable engine. Something that I don't have to open the hood for after the jet change for the weather. If the choices were 408 or 318, I'd go with the 318 because it will last forever. The 408 will need to be freshened fairly quickly comparatively speaking.
When bracket racing started out people would be changing jets like crazy, later they learned that you could just change the dial in with shoe polish, then later they came out with throttle stops where you could just change the numbers in the box, one good thing about a throttle stop is you can run slower but keep almost the same MPH. My cuda would run a 6.60 @ 101 MPH wide open in Super Pro and turn on the throttle stop and would run 7.05 @ 100 MPH in the Pro class, 1-2 MPH in the 1/8th is a big advantage.