Problem with my 5.7

My 03 ram with a 5.7 hemi is putting out two fault codes first is PO300 Random/multiple cylinder misfire and the second is PO301 cylinder #1 misfire.
The plugs where checked and looked okay.
Anyone have any idea what might be causing the misfire?

I was wondering if it might be the coil pack causing both codes seeing how one pack controls two cylinders.