No doubt! Actually Zappa said "drugs are for a**holes."
One of my heroes. You wouldn't know it from that song but he was a musical genius and a pioneer, who accomplished an incredible amount of work in his lifetime. He never gave up, through accidents, lawsuits, government targets, or illness.
The Deep Purple song "Smoke On The Water" was written about the night when Zappa's band played at the Montreaux Casino in Geneva and some idiot fired a flare towards the stage and the place burned to the ground.
He even has species of fish, jellyfish, bacteria and an asteroid named after him!