Holley 500 CFM 2 Barrel #0-4412S on a Slant 6

"but the difference won't be that drastic."

354 / 500??? Sounds pretty drastic to me (41 percent???)

It all depends on what you wanna call gospel. I don't believe everything I read....and I have DONE the swap from a 500 Holley 2 barrel to a 500 4 barrel.