Can a Ford 8.8 handle a big block?

Given the going rate for 8 3/4 rear ends, I'm seriously thinking about the Explorer 8.8 rear end swap. But I have no idea if it would handle my plans for a 400 to 451 stroker build.

The car will be mostly street and I may do a strip every now and then, but it's mostly for street and cruising.

I know the 8.8s were used in cobras etc, but has anyone used one behind a mopar big block?