Interchanges

About the pistons you can bore the block out enough. IF and that's a big IF the cyl wall is thick enough and on some blocks (very few like one out of 1000) are able to handle it. Personally I don't see any advantage you could raise the compression up a little and accomplish the same thing. and have a much stronger block. Reall all the 6.1 and 5.7 parts will bolt together. Without Amy modification with the exception on the pistons.

About the cam installing a 6.1 cam in a 5.7 will not remove or disable MDS. It won't even effect it at all it would still function. The only thin it will dk is net you a little more power on the top end of the rpm range and you will loose a little tq on the low end.