Should you run a car without a thermostat?

Thanks for all the input.I ran the car for 4 hours today with no pinging whats so ever.Ran at 170 degrees all day.So do i leave the vacuum advance hose off and leave the carb port pluged?Or do i just get the distrubator curbbed and put lighter springs on the weights.Will i loose much bottom end with the setup i have now.I put one of those new aluminum 600 holleys on it.They are 5 lbs lighter than the origanals.Runs real good right out of the box.Thanks