A typical 500HP stroker like we build should stay fresh for a min. of 50,000 miles. The only wear is going to be the bore and skirts like most common V8's. There will be slightly more wear because of the added stroke, but it should be minimal given the tall deck height and 6.123 rod.
Now if you drive the thing super hard, race it alot and street drive it everywhere it might wear out sooner...I would expect that with ANY engine not just a stroker.
Consistent oil changes, clean air filters, periodic lash checking and keeping it cool will make sure it will last a long time as with any engine but especially a performance engine. Good oil is also very important!!
