Two questions on a 400 build

There's nothing wrog with running an offset ground crank BUT it's only as good as the guy doing the grinding. Be very careful who you pick to do the work for you.
As far as the 4 speed is concerned, I say run it! Just be sure that your crank is drilled for the pilot bushing.

Ted
if you offset grind the crank and are going to make serious power you should have the crank re-hardened. By the time you add up doing all thr machine work you are usually close to the cost of a new piece form 440 source. If cost is the issue build a 451 these are great motors! 451 with a comp xtreme lift 564 hyd. with 44o source heads should produce 550 to 575 horse with about the same torque. A little tip on the 440 source heads! after initial assembly you will have to re-torque the head bolts 2 more times after you run it a while. a good time to do it is at the 2 first oil changes after break in. The aluminum is not hardened to level of higher priced heads! We had a set recently that popped a gasket and it took very little torque to loosen the arp bolts...highest was 59 ft lbs. lowest was 19 ft lbs. so be aware of that issue! I hope this helps you as I to challenge myself to build things cheaply! My goal was to build a 10 second mopar for a total of 10 grand! The car runs 11s on the motor and 10s on the spray! 440 with 11 to 1 compression 440 source heads ported to flow 313 at .600 the 564 comp cam with 1.6 rollor rockers 391gears in the 3400 lb dart sport. go to you tube and look up...dart sport street races vette and you will see it make a motor pass! good luck on your build!