Can I use the defroster if I have bypassed the heater core?

It is super easy in a A body.

I would say "fairly easy" if a non-factory AC car. If factory air, the heater core is behind the AC evaporator and I recall you have to vent the refrigerant to remove the climate box. At least I had to on my 69 Dart. If so, and you have Freon, consider alternative refrigerants.