Interest in Performance Parts for slants?

how do you think a manifold set up for EFI would sell?

It needs to be different enough from a modified carburetor manifold to capture the attention of the prospective buyer. An equal length runner, fabricated tube manifold (not unlike the Ford Motorsport version of the 93 Cobra manifold) with 16" to 18" runners rolled back over themselves and into a large plenum, barrel style, might do the trick.
Such a manifold would occupy roughly the same real-estate as the former intake, carburetor, and air cleaner. It should clear the master cylinder and stock hood easily. Orient the throttle body mounting flange on the right side of the plenum to shoot the air intake tube over the rocker cover and into the space over the right inner fender. Making it out of steel tube instead of aluminum would possibly save time and money, would be very nearly as light, and the mixture going through it couldn't care (the original Pontiac fuel injection of 1957 used just a manifold). Add into the mix a matching fuel rail with a mount for a fuel pressure regulator and you've got a winner.
As has been stated here many times, those in the slant six crowd are noted for being cheap screws. That said, I personally have observed what happens to some of them when exposed to an aluminum IR manifold and set of three matching DCOE Webers, so I would guess if you can come up with something that captures their imagination and keep the price down near other more conventional offerings, you might just have a winner.