i adjust mine frequently and i have never felt any difference . i dont wear tires unevenly and it doesnt look affected. not to say that it doesnt change...but not enough for me to worry about it..my $0.02
If you make big adjustments, it's more, small adjustments, it's less.
The real question is why do you adjust them frequently? I set my ride height once, got an alignment and have never needed to touch them again in the last 7 years.
