E85 carbed 6.1

From what I've read and know about the stuff you mostly just have to jet the carb up to account for the lower power density of the fuel (need ~30% more fuel for the same power). You may not even have to touch the MSD settings, though you could probably bump the timing up a little since it's a higher octane fuel. E85 can actually be tuned to make more power than gas because of that, but you have to dump so much fuel in you loose an awful lot of miles per gallon if you care about that.