Yes.
And even if the goal is big hp, the stock castings have a decent amount of room to get into 500's hp range.
Stock port volumes are in the 155-160 range...and when ported to the 260-285cfm, approach 175-190 cc.
I currently have some 915 J heads at 186cc's and 273-282 cfm @.500-.530 lift which is without a doubt enough to allow a 410cid sb to dip into the 500's HP range. And it will also rev high 6's just fine.