carb/cam help

I have a 74 duster it was originally a slant six auto and I'm making it a 318 4 speed daily driver/ weekend test and tune car I have an 8 1/4rear for it I was told to run q 488 cam and a holley 600 I guess what I'm asking is does that sound like a decent set up and would I be able to get away with using a carb with vacuum secondaries or should I find a carb with mechanical secondaries oh my intake is a weiand dual plane thanks for all the help