You can save some money by opening an account with FedEx. I fill out the label & shipping form with account #, take everything to the FedEx location and they charge my on-file credit card. They say you save up to 16%. I've always liked their detailed tracking too.
USPS seems to be less expensive when you ship stuff weighing a few pounds or less. But the Priority Flat Rate Boxes can be a deal where you can print & pay for them online and save a bit too after opening an account. Take it to the PO, they confirm and packages are on their way!
I collect boxes & packing material from work to use for shipping. Not fun storing the stuff, but it sure comes in handy when you gotta "insulate" some items and reinforce the boxes.