500hp 408 with Hi-Po 340 Manifolds?

FAST cars should not be compared to anything the average (or even some above average) enthusiasts might put together. I've been involved in them an you will spend (and be willing to spend) twice the cash or more to make the power levels that are reached with mandatory stock appearing parts vs. performance aftermarket parts. Also you have to make well beyond the "normal" power range for the ET because so much is squandered through bad exhaust and not being able to jump on it out of the hole. It's not even close to Stock Eliminator.. It's a special field.
In my opinion - aside from the personal reasons for wanting one or the other - you won't make the power required with those heads or those manifolds with a hydraulic roller. You will need to use a custom solid roller, more static compression, and your power range will be at a higher rpm range than you would typically associate with a 4" engine. It can be done (and has - even been exceeded by a lot) but it takes a lot more money, knowledge, and effort to make it with manifolds than with headers.

Makes sense.

The original poster specs a quasi stock looking motor. A little more open than FAST rules. If I'm interpreting right?:

any intake
any carb
any cast iron head
hi po cast iron exhaust manifolds

I'm guessing street available pump 91? octane gas?

Mopar, would open aftermarket intake, carb, heads (indy x, W2?) make it a little less expensive and easier to get to 500 hp?