1966 Dart troubleshooting

One simple fix is to try to clear the idle circuit at idle mixture screw. From the present setting lightly screw it in while counting exact turns. Then screw it all the way out, clean it with a shop towel and carb cleaner. Then use the red tube on carb cleaner to squirt cleaner in the carb where the mixture screw was removed. Carefully replace screw, lightly seat it and back it off the number of turns you counted.

Dumb question, and the car may not even start without screw, but do I need to use the carb spray while engine is running? Also, do I just spray it in there and let it be? Sorry for the newb questions, this car is my first car in my life that I've been able to tinker with! :D