Big Single exhaust?

Anybody run a big single exhaust? I was planning on dual 2.5", but got to wondering about a big single. I have a 4" cat back on my daily driver f150.

2 1/4 off the manifold (y-pipe) in to 3" exhaust the rest of the way back my new neighbor is an exhaust shop owner. I asked him and he told me this was the most common on fords