That is why they put the paint on the lifters. The paint is used for the lifter installers to put the bleed hole up so the lifters prime easier/faster.
As long as the lifters prime (stop ticking) you are ok. Having the lifter upside down will allow them to loose their prime faster (bleed down) when the engine is not running and take a little longer to pump up when started. As long as they pump up ok, they will be ok.
But for the price of a gasket as stated above, you can put the oil holes up and then not have to worry....