Spark Scatter

Is there any way the 2 pickup wires from the distributor could be reversed? If you are using the factory 73 wiring harness and nothing has changed at the distributor side (double-bullet connector) or the ECU side (big 5-pin connector), it should be correct. I know that when people wire their own, like to a GM HEI module, they often get the pickup wires reversed and then the timing is erratic, and the spark fires when the pickup is between reluctor teeth, not aligned with one.
now that's sounds like experience talking............Artie