Intake manifold doesn't fit right

I'm wondering about the need for that center exhaust crossover passage. On this manifold, like a stock manifold, there is a passage for that exhaust crossover, but on other Edelbrock manifolds, there is no passage. I've read that there are carb fuel boiling problems and wonder if they are related to the exhaust crossover passage. So would it create a problem if the center plug in the intake manifold was not removed when used with a stock or aftermarket manifold with the exhaust crossover passage?