Talk me into Fenderwell Headers

I'm not - nor will I ever be concerned with originality with this car or any car I ever build. I know some people are and that's fine. Just not for me. This car is a 318 auto on the column car.... but no longer. So I have no reservations cutting the inner fenders as long as structural integrity isn't a concern as stated above by another member. I worry about damaging them from throwback off the front tires and the front tires themselves. What's the max tires size that can be run with 2" fenderwells?