stand alone EFI for gen3 hemis

Ok, this has peaked my interest. Can't his, or MS3 be useable with the stock 6.1 or 6.4 intake system? In other words, can I do away with the Drive-By-Wire which I'd prefer not to use. In other words, a plug and play?
I realize that this was probably covered earlier in this posts, but I'm kind of slow at times.