I have always plugged them and fattened the secondary jets. Has always worked good for me in the past. Current 750 on my 340 has 2nd block PV plugged and runs fine. Nice crisp throttle response w 70/82 jets and a 6.5 PV on primary side. Did have slight hesitation and a quick dead spot as soon as secondaries started to open, till I put the 82s in secondary side, and went little bigger on the secondary squirters.