Holley secondaries won't open

Think of the flow rate on a vacuum secondary Holley as being an "up to" number. That's why you can bolt a fairly large carb and still have smooth street performance. The carb will only flow as much air as the engine requires.

In the original post you pretty much identified the problem. A stock 2 barrel intake is like a restrictor plate. The primaries on that Holley will flow about the same as the mounting flange on that manifold. Grab a Performer intake off eBay and a lot of your problems will go away. But if you still have a stock cam and exhaust don't expect miracles
A lot of wisdom here IMO. I am not sure that the stock 2bbl intake flange is THAT restricted but is certainly not going to flow anywhere close to 750 cfm.

And good question on the cam. I put a 4bbl carb AND 4 bbl manifold on an old Ford 292 truck engine once way in the past, and the change was not very noticeable. That low duration truck cam made it pretty much a waste of effort. So, the OP can help to tell if he has a cam in this engine.