I run 4.56 gears with 28 inch tires and a low first gear and it does not seem like to much gear with my W2 headed 408 SB, but my car weights over 3400 lbs with me in it.
I shift at 6800 and go through the lights at 7000.
My car has run the best of 11.06 at over 121MPHs in FULL STREET TRIM, full exhaust hooked up, spare tire in the trunk, heater, stereo, 91 octane fuel and street tires.
I have put over 9500 miles on the motor so far plus around 65 1/4 passes so far this is with a small solid roller cam.
Car has gone 11.11 with a 3.73 gear that I run in the car most of the time.