What options for O/D behind a S/6?

Be prepared to do this then. Snip, snip, cut, fabricate something then weld and weld some more. Slant six's are generally tuned pretty poorly for performance, so trying to drive a Mopar overdrive with one will really tax it. They take more power to drive than almost anything else. They're not known for their efficiency.

Gear Vendors are kind of like halfway to overdrive with driveline clunks and vibrations. Splitting gears from 1l, 1h, 2l, 2hm 3l 3h is very hard to do well. Almost impossible for the average guy, so don't put too much stock into that drag strip dreaming fallacy.

You best hope a certain Gear Vendor lover never sees this, he will rip you a new one....Have to wonder if a / has enough torque to warrant an od trans? Our 99 Exploder with a 4.0 SOHC with 200k miles on it is starting to struggle with staying locked up in od and then often times just staying in od. Our car is set op for a 4l80e, the torsion bar cross member needed to go. Keep in mind that the t-bars twist, so once the rigidity is gone you will have problems. There are ways to deal with it, just hunt for the thread by the fellow that swapped a t-56 into his car and made a very beefy looking brace to replace what he cut out. Or you could just swap in a HE or AlterK....

An auto OD & cost efficient, in an A-body at least, is sort of an oxy-moron....best of luck to you....