Slant 6 4 barrel carb

Is it advisable to replace the ignition coil with a stronger output voltage?...I have read someone installed a 45,000 v coil and increased spark plug gap...if this is done, does any other item need to be replaced ie..ballast resister, electronic ignition, plugs, dist components etc etc?

After rebuilding and re-installing my single barrel holley carb, she starts and runs in cold weather, the choke and high idle finally work, it feels good to rebuild something the first time and have immediate success doing so. For all you guys who've done this for years, it will seem like a small deal, but I now feel ready to take on the 4 barrel. I have read that the camshaft can be replaced WITHOUT removing the block, is this true?