quickest et,s on an edelbrock carby

What about mechanical secondaries on a carter or Eddy.?
I don't have enough vacuum for vacuum secondaries.
Also, couldn't a Thermoquad be a decent performance choice?

All 3 late Carter carbs and Edelbrock carbs are mechanical secondary carbs.
The AFB uses a counter weighted secondary air door. It opens with engine demand. They call it a velocity door.
The AVS and the TQ use a spring loaded air door. Twist the spring tighter for a later opening, loosen the spring for an eaier opening.

So, the need for vacuum is out. The worry of lack of vacuum is out.

The Thermo Quad was designed and but as a race carb first and then later used on everyday engines. They are indeed a good carb but also carry limitations. First would be the available tuning parts required. Secondly there spreadbore design limits the intake. Fuel distribution isn't the best ether. But they can and will perform really well.

The TQ comes in a small and large primary as well as the hard to find race version.
The race version shares itself with the first year TQ but not the rest of them.
While the Holley has enough tuning parts to drive you made and spend lots of money on them, the Carter/Edel. Carbs only have a few items. Dialing the fuel curve in on these carbs can not be brought to the level of a better than basic Holley. You will have to modify the Carter/Edel. To get the carb to a "OK" status at best.

I myself like to run a TQ and have gotten (or used to be) very good at them. The best was, I would get the carb and rebuild it with a new kit for under $100! 800-850 cfm's for a $100. Not having a lot of money at the time, I thought you would have to be crazy not to go this route even though it wasn't as tuneable.

A basic Holley, like what you would find on any OE car of the day is more tuneable. But also limited. Spend big bucks on a upper level Holley and it can get crazy.