Help with 360, too much comp?

OK, going by the premise you want to use Eddie heads, 93 octane and the pistons. With the combination you described you should not have any real issues. You can help with the thicker head gaskets to lower it a bit.

Just a note, I used 191 pistons with about 11.8 compression and had no issues with a .528 purple cam and generally the same setup you described. You could call Hughes and have them help you find a better selection in cams.