68 truck 318 cam. How big can i go?

That's not a low cr build they squeeze 10:1 out of it.
If you use that as the basis for your build, you'll need more cam, cr and head flow to gain 50 more horsepower.

Those 400hp 318 recipes that float around would be good for a light deep geared A body but wouldn't be very fun in a heavy under geared truck.

I bet a 68 truck weighs about the same as a A-body.
The trucks have pretty steep gears, most are 3.91 from the factory.
They make for cheap fun rides.

Here is a pic of my old 71 that I totaled, it was a daily driver reliable old truck, not the rusty one I talked about earlier.