Driveline Hitting underside of floor (at rear)

All the rear end ratio calculators I've used say with a 25.7" tall tire (which is what I have: 245/45-18) that is the ratio I need to run at 2,200 RPM at 60 mph.

That's about right, I get 2165 RPM at 60 MPH. But you did say this: "I am worried about the low end if we put 2.76:1 gears in it." You should be. It's going be be slow taking off from a stop. Why is "2200RPM @ 60 MPH" so important? With 3.23 gears it'll be turning 2533 RPM. What's wrong with that? Heck, I have 3.55s in my Dart (340 engine) and it runs great at 2800 RPM at 60 MPH.