Holley 2210 two barrel flooding.

Reviving an old thread because it has to do with the 2210 Holley and I didn't feel the need to.start a new thread. I'm going to use a stock 73 two barrel 360. The same one in this thread. The question is this. Will this two barrel carb work with a he268 cam. I kindof want to experiment and see if this cam will give be some better gas mileage and torque. Right now with the tiny two barrel cam only gets 17 mpg and cuts out at 4500rpm. I am going to Change out springs for the cam. Would this 2210 Holley be enough? Do you suppose I will have to rejet it or anything? I already own this cam and I thought it would be nice to see it get put to use since I'm going to go with a bigger cam for my duster.