65 170 vacuum advance or not?

I had all the vacuum lines hooked up according to the factory service manual eventhough I'm using a Edelbrock 600. Should I just run the vacuum hose from the vacuum advance to the carburetor and plug up the vacuum bypass valve in the water pump housing and the OSAC valve?

Yes, I would eliminate the OSAC valve, per Dan's instruction. I cannot remember which port on the Edelbrock is ported. I THINK it is the one on the passenger's side in the front. That's where the distributor should be plugged in.