I mean, you put them in the tire and drive. That's about all there is to it.
My brother runs them in all his mopars (and I have them in my Duster's tires).
The only time I ever noticed a difference (or an advantage over wheel weights, I should say) was when I was in the oil patch and had them in my work truck's tires- after driving on muddy roads, the mud sticking inside the rims didn't affect balance nearly as much as with static wheel weights- when mud built up, the beads would redistribute themselves to smooth out the ride (to an extent, of course- a few ounces of balance beads won't correct for 5 or 10 pounds of mud in one spot on the rim lol).
