Yes, and it could result in positive deck height too which would not work well. You'd have to start way with pistons way down in the hole or some folks shave them. The size of the bores won't matter much- you won't have perfect clearance stroking a 318 or 340 either. The 360 crank would likely be fine, but the 4" would need clearanced. As said- it'd take a lot to bring the compression down to something reasonable.
